{"id":7460,"date":"2020-03-16T14:38:00","date_gmt":"2020-03-16T05:38:00","guid":{"rendered":"http:\/\/bmk.hiroshima-u.ac.jp\/?p=7460"},"modified":"2020-06-05T14:52:35","modified_gmt":"2020-06-05T05:52:35","slug":"ichikawa202003","status":"publish","type":"post","link":"https:\/\/bmk.hiroshima-u.ac.jp\/?p=7460","title":{"rendered":"MRI\u691c\u67fb\u3068AI\u3092\u7528\u3044\u305f\u3046\u3064\u75c5\u306e\u9ad8\u3044\u7cbe\u5ea6\u306e\u5224\u5b9a\u306b\u3088\u308b\u65b0\u305f\u306a\u8a3a\u65ad\u6cd5\u3092\u958b\u767a\u3057\u307e\u3057\u305f\uff08\u5ca1\u672c\u3000\u6cf0\u660c\u5148\u751f\u30fb\u5e02\u5ddd\u3000\u5948\u7a42\u5148\u751f\uff09"},"content":{"rendered":"\n

\u3000\u5f53\u30bb\u30f3\u30bf\u30fc\u306e\u5ca1\u672c\u6cf0\u660c\u6559\u6388\u3001\u5e02\u5ddd\u5948\u7a42\u7279\u4efb\u52a9\u6559\u3092\u59cb\u3081\u3068\u3057\u305f\u3001\u56fd\u969b\u96fb\u6c17\u901a\u4fe1\u57fa\u790e\u6280\u8853\u7814\u7a76\u6240(ATR) \u8133\u60c5\u5831\u901a\u4fe1\u7dcf\u5408\u7814\u7a76\u6240\u3001\u91cf\u5b50\u79d1\u5b66\u6280\u8853\u7814\u7a76\u958b\u767a\u6a5f\u69cb(QST)\u3001\u662d\u548c\u5927\u5b66\u3001\u6176\u61c9\u5927\u5b66\u3001\u4eac\u90fd\u5927\u5b66\u3001\u6771\u4eac\u5927\u5b66\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u5b89\u9759\u6642\u306b\u64ae\u50cf\u3055\u308c\u305f\u6a5f\u80fd\u7684\u78c1\u6c17\u5171\u9cf4\u753b\u50cf(fMRI)\u30c7\u30fc\u30bf\u3092\u57fa\u306b\u3001\u3046\u3064\u75c5\u306e\u4e2d\u6838\u7fa4\u3068\u3055\u308c\u308b\u30e1\u30e9\u30f3\u30b3\u30ea\u30a2\u7279\u5fb4\u3092\u4f34\u3046[1]<\/sup>\u3046\u3064\u75c5\u3092\u5224\u5225\u3059\u308b\u65b9\u6cd5(\u3046\u3064\u75c5\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc)\u306e\u958b\u767a\u3068\u3001\u6297\u3046\u3064\u85ac\u6cbb\u7642\u306b\u3088\u308b\u8133\u6a5f\u80fd\u7d50\u5408\u306e\u5909\u5316\u306e\u9055\u3044\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u3001\u56fd\u969b\u8a8c\u300cScientific Reports\u300d\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\uff08\u672c\u5b66\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a>\uff09\u3002
\u3000\u3053\u308c\u306b\u3088\u308a\u3001MRI\u691c\u67fb\u306b\u3088\u308b\u3046\u3064\u75c5\u306e\u4e2d\u6838\u7fa4\u306e\u5224\u5b9a\u3084\u3001\u6297\u3046\u3064\u85ac\u306b\u3088\u308b\u5909\u5316\u304c\u307f\u3089\u308c\u306a\u3044\u8133\u6a5f\u80fd\u7d50\u5408\u3078\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306b\u3088\u308a\u3001\u65b0\u305f\u306a\u3046\u3064\u75c5\u306e\u6cbb\u7642\u6cd5\u958b\u767a\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

\"\"
\u672c\u7814\u7a76\u306e\u6982\u8981<\/figcaption><\/figure>\n\n\n\n

\u3000\u4e16\u754c\u4fdd\u5065\u6a5f\u95a2(WHO)\u306e\u5831\u544a\u3067\u306f\u30012030\u5e74\u306b\u306f\u3046\u3064\u75c5\u304c\u4e16\u754c\u7684\u306b\u75be\u75c5\u8ca0\u8377\u306e\u7b2c\u4e00\u4f4d\u3068\u306a\u308b\u3053\u3068\u304c\u4e88\u6e2c\u3055\u308c\u3066\u3044\u307e\u3059\u3002 \u305d\u306e\u4e00\u65b9\u3067\u3001\u85ac\u7269\u7642\u6cd5\u3084\u7cbe\u795e\u7642\u6cd5\u3092\u53d7\u3051\u308b3\u5206\u306e2\u306e\u75c7\u4f8b\u304c\u5b8c\u5168\u306b\u53cd\u5fdc\u305b\u305a\u3001\u6cbb\u7642\u306b\u53cd\u5fdc\u3057\u305f2\u5206\u306e1\u3057\u304b\u5bdb\u89e3\u3092\u7dad\u6301\u3057\u306a\u3044\u306a\u3069\u3001\u85ac\u7269\u6cbb\u7642\u306e\u9650\u754c\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u304c\u55ab\u7dca\u306e\u8ab2\u984c\u3067\u3059\u3002<\/p>\n\n\n\n

\u3000\u672c\u7814\u7a76\u3067\u306f\u3001\u7cbe\u795e\u75be\u60a3\u7c21\u6613\u69cb\u9020\u5316\u9762\u63a5\u6cd5(MINI)[2]<\/sup>\u306b\u3088\u308a\u5224\u5b9a\u3057\u305f\u3046\u3064\u75c5\u60a3\u800592\u540d\u3068\u5e74\u9f62\u6027\u5225\u3092\u5408\u308f\u305b\u305f\u5065\u5e38\u800592\u540d\u306e\u3046\u3061\u3001\u30e1\u30e9\u30f3\u30b3\u30ea\u30a2\u7279\u5fb4\u3092\u4f34\u3046\u3046\u3064\u75c565\u540d\u3068\u5065\u5e38\u800565\u540d\u306e\u8a08130\u540d\u306e\u5b89\u9759\u6642\u8133\u6a5f\u80fd\u7d50\u5408\u30c7\u30fc\u30bf[3]<\/sup>\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3001\u4eba\u5de5\u77e5\u80fd(AI)\u3001\u8907\u6570\u306e\u6a5f\u68b0\u5b66\u7fd2\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0[4]<\/sup>\u3092\u9069\u7528\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u30e1\u30e9\u30f3\u30b3\u30ea\u30a2\u7279\u5fb4\u3092\u4f34\u3046\u3046\u3064\u75c5\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u958b\u767a\u3092\u884c\u3044\u307e\u3057\u305f\u3002
\u3000\u88ab\u9a13\u8005\u306e\u8133\u6a5f\u80fd\u6d3b\u52d5\u306f\uff13\u30c6\u30b9\u30e9\u306eMRI\u88c5\u7f6e\u306b\u3088\u308a\u7d0410\u5206\u9593\u64ae\u50cf\u3057\u3001\u64ae\u50cf\u4e2d\u306f\u30e2\u30cb\u30bf\u30fc\u4e2d\u592e\u306b\u8868\u793a\u3055\u308c\u308b\u5341\u5b57\u30de\u30fc\u30af\u3092\u898b\u306a\u304c\u3089\u5b89\u9759\u306b\u3057\u3066\u7720\u3089\u306a\u3044\u3088\u3046\u306b\u6559\u793a\u3057\u307e\u3057\u305f\u3002\u8133\u6a5f\u80fd\u753b\u50cf\u89e3\u6790\u306f\u3001\u8133\u6e9d\u30a2\u30c8\u30e9\u30b9\u306b\u5f93\u3063\u3066\u5168\u8133137\u9818\u57df\u304b\u3089\u6642\u7cfb\u5217\u30c7\u30fc\u30bf\u3092\u62bd\u51fa\u3057\u3001\u6642\u7cfb\u5217\u76f8\u95a2\u3092\u307e\u3068\u3081\u305f\u76f8\u95a2\u884c\u5217\u30c7\u30fc\u30bf(9316\u306e\u7279\u5fb4\u91cf)\u3092\u500b\u4eba\u6bce\u306b\u4f5c\u6210\u3057\u307e\u3057\u305f\u3002\u5168\u8133\u3088\u308a\u5f97\u3089\u308c\u305f\u8133\u6a5f\u80fd\u7d50\u5408\u304b\u3089\u300110\u500b\u306e\u8133\u6a5f\u80fd\u7d50\u5408\u304c\u30e1\u30e9\u30f3\u30b3\u30ea\u30a2\u7279\u5fb4\u3092\u4f34\u3046\u3046\u3064\u75c5\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u62bd\u51fa\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc(\u5224\u5225\u5668)\u3092\u7528\u3044\u3066\u30e1\u30e9\u30f3\u30b3\u30ea\u30a2\u7279\u5fb4\u3092\u4f34\u3046\u3046\u3064\u75c5\u304c\u5224\u5225\u738784% (AUC 0.91)[5]<\/sup>\u3068\u9ad8\u3044\u7cbe\u5ea6\u3067\u5224\u5225\u3067\u304d\u307e\u3057\u305f\u3002\u3053\u306e\u5224\u5225\u5668\u306f\u3001\u7570\u306a\u308b\u65bd\u8a2d\u306e\u72ec\u7acb\u3057\u305f\u30c7\u30fc\u30bf\u30bb\u30c3\u30c8\u3067\u3082\u6709\u610f\u306a\u5224\u5225\u7cbe\u5ea6(\u6c4e\u5316\u6027\u80fd)[6]<\/sup>\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u6cbb\u7642\u958b\u59cb\u5f8c6-8\u9031[7]<\/sup>\u306b\u518d\u64ae\u50cf\u3092\u884c\u3063\u305f\u4e00\u90e8\u306e\u75c7\u4f8b\u306b\u304a\u3044\u3066\u6297\u3046\u3064\u85ac\u3067\u3042\u308b\u9078\u629e\u7684\u30bb\u30ed\u30c8\u30cb\u30f3\u518d\u53d6\u308a\u8fbc\u307f\u963b\u5bb3\u85ac(SSRI) [8]<\/sup>\u306e\u6cbb\u7642\u306b\u3088\u308b\u5909\u5316\u306b\u3064\u3044\u3066\u306e\u691c\u8a0e\u3057\u305f\u3068\u3053\u308d\u300110\u500b\u306e\u8133\u6a5f\u80fd\u7d50\u5408\u306e\u3046\u3061\u3001\u5909\u5316\u304c\u307f\u3089\u308c\u306a\u3044\u7d50\u5408(\u5de6\u80cc\u5916\u5074\u524d\u982d\u524d\u91ce\u3068\u5f8c\u90e8\u5e2f\u72b6\u56de\/\u6954\u524d\u90e8\u306e\u6a5f\u80fd\u7d50\u5408[9]<\/sup>)\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\u3000\u672c\u7814\u7a76\u306f\u3001\u5168\u8133\u30c7\u30fc\u30bf\u304b\u3089\u3046\u3064\u75c5\u306e\u4e2d\u6838\u7fa4\u3068\u3055\u308c\u308b\u30e1\u30e9\u30f3\u30b3\u30ea\u30a2\u7279\u5fb4\u3092\u4f34\u3046\u3046\u3064\u75c5\u306b\u7279\u7570\u7684\u306a\u5b89\u9759\u6642\u8133\u6a5f\u80fd\u7d50\u5408\u3092\u62bd\u51fa\u3057AI\u3092\u7528\u3044\u3066\u9ad8\u3044\u7cbe\u5ea6\u3067\u5224\u5b9a\u3067\u304d\u308b\u3053\u3068\u3001\u307e\u305f\u3001\u6297\u3046\u3064\u85ac\u6cbb\u7642\u306b\u3088\u308a\u5909\u5316\u304c\u307f\u3089\u308c\u306a\u3044\u8133\u6a5f\u80fd\u7d50\u5408\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u3092\u521d\u3081\u3066\u660e\u3089\u304b\u306b\u3057\u305f\u7814\u7a76\u3067\u3059\u3002<\/p>\n\n\n\n

\"\"
\u8133\u6a5f\u80fd\u7d50\u5408<\/figcaption><\/figure>\n\n\n\n

\u3010\u53c2\u8003\u3011
[1] \u201c\u30e1\u30e9\u30f3\u30b3\u30ea\u30a2\u7279\u5fb4\u201d\u3092\u4f34\u3046\u3046\u3064\u75c5
\u3000\u201c\u30e1\u30e9\u30f3\u30b3\u30ea\u30a2\u7279\u5fb4\u201d\u3092\u4f34\u3046\u3046\u3064\u75c5\u306f\u3001\u69d8\u3005\u306a\u30b5\u30d6\u30bf\u30a4\u30d7\u3082\u6307\u6458\u3055\u308c\u308b\u3046\u3064\u75c5\u306b\u304a\u3044\u3066\u3001\u751f\u7269\u5b66\u7684\u5747\u8cea\u6027\u304c\u9ad8\u304f\u3001\u3046\u3064\u75c5\u306e\u4e2d\u6838\u7fa4\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002
\u3000DSM\u22125\u7cbe\u795e\u75be\u60a3\u306e\u8a3a\u65ad\u30fb\u7d71\u8a08\u30de\u30cb\u30e5\u30a2\u30eb\u7b2c5\u7248(2014)\u306b\u3088\u308c\u3070\u3001\u30e1\u30e9\u30f3\u30b3\u30ea\u30a2\u7279\u5fb4\u306f\u4ee5\u4e0b\u306e\u3088\u3046\u306b\u8aac\u660e\u3055\u308c\u307e\u3059\u3002
\uff21\uff0e\u73fe\u5728\u306e\u30a8\u30d4\u30bd\u30fc\u30c9\u306e\u6700\u3082\u91cd\u5ea6\u306a\u671f\u9593\u306b\u3001\u4ee5\u4e0b\u306e\u3046\u3061\uff11\u3064\u304c\u5b58\u5728\u3059\u308b\uff1a
\uff11\uff0e\u5168\u3066\u306e\u3001\u307e\u305f\u306f\u307b\u3068\u3093\u3069\u3059\u3079\u3066\u306e\u6d3b\u52d5\u306b\u304a\u3051\u308b\u559c\u3073\u306e\u55aa\u5931
\uff12\uff0e\u666e\u6bb5\u5feb\u9069\u3067\u3042\u308b\u523a\u6fc0\u306b\u5bfe\u3059\u308b\u53cd\u5fdc\u306e\u6d88\u5931(\u4f55\u304b\u3088\u3044\u3053\u3068\u304c\u8d77\u3053\u3063\u305f\u5834\u5408\u306b\u3082\u4e00\u6642\u7684\u306b\u3055\u3048\u3001\u305a\u3063\u3068\u3088\u3044\u6c17\u5206\u306b\u306a\u3089\u306a\u3044)

\uff22\uff0e\u4ee5\u4e0b\u306e\u3046\u30643\u3064(\u307e\u305f\u306f\u305d\u308c\u4ee5\u4e0a)\uff1a
\uff11\uff0e\u306f\u3063\u304d\u308a\u3068\u4ed6\u3068\u533a\u5225\u3067\u304d\u308b\u6027\u8cea\u306e\u6291\u3046\u3064\u6c17\u5206\u304c\u3042\u308a\u3001\u6df1\u3044\u843d\u80c6\u3001\u7d76\u671b\u3001\u304a\u3088\u3073\/\u307e\u305f\u306f\u9670\u9b31\u3055\u3001\u307e\u305f\u306f\u3044\u308f\u3086\u308b\u7a7a\u865a\u611f\u306b\u3088\u3063\u3066\u7279\u5fb4\u3065\u3051\u3089\u308c\u308b
\uff12\uff0e\u6291\u3046\u3064\u306f\u6c7a\u307e\u3063\u3066\u671d\u306b\u60aa\u5316\u3059\u308b
\uff13\uff0e\u65e9\u671d\u899a\u9192(\u3059\u306a\u308f\u3061\u3001\u901a\u5e38\u306e\u8d77\u5e8a\u6642\u9593\u3088\u308a\u5c11\u306a\u304f\u3068\u30822\u6642\u9593\u65e9\u3044)
\uff14\uff0e\u8457\u3057\u3044\u7cbe\u795e\u904b\u52d5\u7126\u71e5\u307e\u305f\u306f\u5236\u6b62
\uff15\uff0e\u6709\u610f\u306a\u98df\u6b32\u4e0d\u632f\u307e\u305f\u306f\u4f53\u91cd\u6e1b\u5c11
\uff16\uff0e\u904e\u5ea6\u307e\u305f\u306f\u4e0d\u9069\u5207\u306a\u7f6a\u60aa\u611f<\/p>\n\n\n\n

[2] \u7cbe\u795e\u75be\u60a3\u7c21\u6613\u69cb\u9020\u5316\u9762\u63a5\u6cd5(MINI)
\u3000\u7cbe\u795e\u969c\u5bb3\u306e\u8a3a\u65ad\u306e\u305f\u3081\u306e\u77ed\u6642\u9593\u3067\u65bd\u884c\u53ef\u80fd\u306a\u69cb\u9020\u5316\u9762\u63a5\u3002\u6a19\u6e96\u5316\u3055\u308c\u305f\u8cea\u554f\u9805\u76ee\u3092\u7528\u3044\u306a\u304c\u3089\u3001\u7d0415\u5206\u7a0b\u5ea6\u3067\u5b9f\u65bd\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n

[3] \u5b89\u9759\u6642\u8133\u6a5f\u80fd\u7d50\u5408
\u3000\u8133\u306f\u5b89\u9759\u72b6\u614b\u306b\u3042\u3063\u3066\u3082\u81ea\u767a\u7684\u306a\u6d3b\u52d5\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3092\u6a5f\u80fd\u7684MRI\u3067\u8a08\u6e2c\u3059\u308b\u3068\u3001\u8133\u6d3b\u52d5\u72b6\u614b\u3092\u8868\u3059\u4fe1\u53f7\u5024(BOLD\u4fe1\u53f7\u5024)\u304c\u6642\u9593\u306e\u7d4c\u904e\u3068\u3068\u3082\u306b\u3086\u3089\u3050\u73fe\u8c61\u3068\u3057\u3066\u89b3\u5bdf\u3055\u308c\u307e\u3059\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u305d\u306e\u9577\u5468\u671f\u6210\u5206(\u5468\u671f10\u79d2\u4ee5\u4e0a)\u306b\u7740\u76ee\u3057\u3066\u3046\u3064\u75c5\u306b\u7279\u5fb4\u7684\u306a\u6642\u9593\u7684\u5909\u52d5\u306e\u691c\u51fa\u3092\u76ee\u6307\u3057\u3001\u8133\u6d3b\u52d5\u3092\u53cd\u6620\u3059\u308bMRI\u4fe1\u53f7(BOLD\u4fe1\u53f7)\u306e\u6642\u9593\u7684\u5909\u52d5\u306e\u76f8\u95a2\u4fc2\u6570\u304b\u3089\u8a55\u4fa1\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u76f8\u95a2\u4fc2\u6570\u306f\u30012\u9818\u57df\u9593\u306e\u8133\u6d3b\u52d5\u306e\u985e\u4f3c\u6027\u304c\u9ad8\u3044\u30681\u306b\u8fd1\u3044\u5024\u306b\u3001\u4e92\u3044\u3092\u6291\u5236\u3057\u3042\u3046\u95a2\u4fc2\u3067\u306f-1\u306b\u8fd1\u3044\u5024\u306b\u3001\u4e92\u3044\u306b\u95a2\u9023\u3057\u306a\u3044\u3068\u304d\uff10\u306b\u8fd1\u3044\u5024\u3092\u53d6\u308a\u307e\u3059\u3002
\u3000\u672c\u7814\u7a76\u3067\u306f\u3001137\u500b\u306e\u5404\u8133\u90e8\u4f4d\u304b\u3089\u4fe1\u53f7\u6ce2\u5f62\u3092\u53d6\u308a\u51fa\u3057\u3001\u5168\u3066\u306e\u8133\u90e8\u4f4d\u30da\u30a2(9,316\u7d44)\u306b\u3064\u3044\u3066\u76f8\u95a2\u4fc2\u6570\u3092\u6c42\u3081\u308b\u3053\u3068\u3067\u3001\u500b\u4eba\u306e\u5168\u8133\u306b\u308f\u305f\u308b\u6a5f\u80fd\u7684\u7d50\u5408\u60c5\u5831\u3092\u542b\u3093\u3060\u8133\u306e\u6a5f\u80fd\u7684\u56de\u8def\u56f3\u3092\u5f97\u307e\u3057\u305f\u3002\u305d\u308c\u305e\u308c\u306e\u8981\u7d20\u304c-1\u304b\u30891\u306e\u9593\u306e\u5024\u3092\u53d6\u308b\u30019,730\u6b21\u5143\u306e\u30d9\u30af\u30c8\u30eb\u3092\u4eba\u5de5\u77e5\u80fd\u6280\u8853\u3067(\u30e1\u30e9\u30f3\u30b3\u30ea\u30a2\u7279\u5fb4\u3092\u4f34\u3046)\u3046\u3064\u75c5\u304b\u5426\u304b\u306e2\u3064\u306e\u30af\u30e9\u30b9\u306b\u5206\u985e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

[4] \u4eba\u5de5\u77e5\u80fd(Artificial Intelligence\uff1bAI)\u3001\u8907\u6570\u306e\u6a5f\u68b0\u5b66\u7fd2\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0
\u3000\u7279\u5fb4\u91cf\u306e\u7d5e\u308a\u8fbc\u307f\u3092\u52b9\u7387\u3088\u304f\u884c\u3046\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u3068\u3057\u3066\u3001\u6b63\u5247\u5316\u30b9\u30d1\u30fc\u30b9\u6b63\u6e96\u76f8\u95a2\u5206\u6790(L1-SCCA)\u3068\u30b9\u30d1\u30fc\u30b9\u30ed\u30b8\u30b9\u30c6\u30a3\u30c3\u30af\u56de\u5e30(SLR)\u3068\u3044\u3046\u4e8c\u3064\u306e\u65b9\u6cd5\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u9769\u65b0\u7684\u4eba\u5de5\u77e5\u80fd\u6280\u8853\u3092\u958b\u767a\u3057\u3001\u30aa\u30fc\u30d0\u30fc\u30d5\u30a3\u30c3\u30c6\u30a3\u30f3\u30b0\u73fe\u8c61\u304c\u8d77\u3053\u308a\u306b\u304f\u3044\u5de5\u592b\u3092\u52a0\u3048\u306a\u304c\u3089\u3001\u5185\u90e8\u30fb\u5916\u90e8\u53cc\u65b9\u306e\u30c7\u30fc\u30bf\u306b\u3064\u3044\u3066\u9ad8\u3044\u7cbe\u5ea6\u304c\u5f97\u3089\u308c\u308b\u5224\u5225\u5668\u306e\u958b\u767a\u304c\u53ef\u80fd\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u6280\u8853\u3092\u7528\u3044\u3066\u3001\u3059\u3067\u306b\u81ea\u9589\u75c7\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3092\u958b\u767a\u3057\u3066\u3044\u307e\u3059 (Yahata et al., A small number of abnormal brain connections predicts adult autism spectrum disorder, Nature communications 2016)\u3002<\/p>\n\n\n\n

[5] AUC (Area Under the Curve)
\u3000\u75be\u60a3\u7fa4\u30fb\u5065\u5e38\u7fa4\u306a\u3069\u306e\uff12\u5024\u5206\u985e\u3092\u884c\u3046\u624b\u6cd5\u306e\u7cbe\u5ea6\u3092\u8a55\u4fa1\u3059\u308b\u6307\u6a19\u3067\u3059\u30020\uff5e1\u306e\u5024\u3092\u3068\u308a\u30011\u306b\u8fd1\u3065\u3051\u3070\u8fd1\u3065\u304f\u307b\u3069\u512a\u308c\u305f\u5206\u985e\u65b9\u6cd5\u3067\u3042\u308b\u3053\u3068\u3092\u8868\u3057\u307e\u3059\u30020.9\uff5e1.0\u306f\u9ad8\u7cbe\u5ea6\u30010.7\uff5e0.9\u306f\u4e2d\u7a0b\u5ea6\u30010.5\uff5e0.7\u306f\u7cbe\u5ea6\u304c\u4f4e\u3044\u3068\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

[6] \u5916\u90e8\u72ec\u7acb\u30c7\u30fc\u30bf\u306b\u304a\u3051\u308b\u6709\u610f\u306a\u5224\u5225\u7cbe\u5ea6(\u6c4e\u5316\u6027\u80fd)
\u3000\u672c\u7814\u7a76\u30d7\u30ed\u30b0\u30e9\u30e0\u3067\u306f\u3001\u4eba\u9593\u306e\u5b66\u7fd2\u3068\u540c\u3058\u3088\u3046\u306b\u3001\u5c11\u6570\u500b\u306e\u30b5\u30f3\u30d7\u30eb\u304b\u3089\u3067\u3082\u5b66\u7fd2\u3057\u3001\u6c4e\u5316\u80fd\u529b\u3092\u62c5\u4fdd\u3067\u304d\u308b\u9769\u65b0\u7684\u306a\u4eba\u5de5\u77e5\u80fd\u6280\u8853\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002
\u3000\u73fe\u5728\u4e3b\u6d41\u306e\u4eba\u5de5\u77e5\u80fd\u6280\u8853\uff08\u305f\u3068\u3048\u3070\u6df1\u5c64\u5b66\u7fd2\u30cb\u30e5\u30fc\u30e9\u30eb\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306a\u3069\uff09\u306b\u306f\u3001\u30d3\u30c3\u30b0\u30c7\u30fc\u30bf\u304c\u5fc5\u9808\u3067\u3001\u5f93\u6765\u6280\u8853\u3067\u306f\u30c7\u30fc\u30bf\u6b21\u5143\u306e\u5c11\u306a\u304f\u3068\u308210\u500d\u306e\u30b5\u30f3\u30d7\u30eb\u304c\u5fc5\u8981\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002
\u3000\u7cbe\u795e\u79d1\u9818\u57df\u3084\u8133\u79d1\u5b66\u306e\u9818\u57df\u3067\u3082\u3001MRI\u753b\u50cf\u304b\u3089\u5f97\u3089\u308c\u308b\u6307\u6a19\u3092\u3082\u3068\u306b\u7cbe\u795e\u75be\u60a3\u72b6\u614b\u3092\u5224\u5225\u3059\u308b\u8a66\u307f\u306f\u3053\u308c\u307e\u3067\u306b\u3082\u591a\u6570\u3042\u308a\u307e\u3057\u305f\u304c\u3001\u3053\u308c\u3089\u306b\u306f\u6570\u5341\u30fb\u6570\u767e\u3068\u3044\u3063\u305f\u5c0f\u898f\u6a21\u306e\u30b5\u30f3\u30d7\u30eb\u3057\u304b\u7528\u3044\u3089\u308c\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3053\u306e\u305f\u3081\u3001\u7814\u7a76\u7528\u306b\u96c6\u3081\u3089\u308c\u305f\u5c11\u306a\u3044\u30c7\u30fc\u30bf\u306b\u3064\u3044\u3066\u306f\u9ad8\u7cbe\u5ea6\u306b\u5224\u5225\u3067\u304d\u3066\u3082\u3001\u4efb\u610f\u306e\u5916\u90e8\u30c7\u30fc\u30bf\u306b\u5bfe\u3059\u308b\u7cbe\u5ea6\u306f\u672a\u691c\u8a3c\u3067\u3042\u3063\u305f\u304b\u3001\u7d71\u8a08\u7684\u306b\u610f\u5473\u306e\u3042\u308b\u7cbe\u5ea6\u306b\u53ca\u3093\u3067\u3044\u306a\u304b\u3063\u305f(\u6b63\u7b54\u738750\uff05\u3068\u8a00\u3046\u5834\u5408\u3082\u3042\u308b)\u3068\u3082\u8a00\u308f\u308c\u307e\u3059\u3002\u3053\u306e\u7406\u7531\u3068\u3057\u3066\u306f\u3001\u5224\u5225\u6cd5\u306e\u958b\u767a\u6bb5\u968e\u3067\u3001\u75be\u60a3\u5c5e\u6027\u3068\u306f\u95a2\u4fc2\u306e\u306a\u3044\u30c7\u30fc\u30bf\u3092\u542b\u3080\u7279\u6027\u307e\u3067\u3092\u53d6\u308a\u8fbc\u3093\u3060\u6a5f\u68b0\u5b66\u7fd2\u304c\u884c\u308f\u308c\u305f\u7d50\u679c\u3001\u5916\u90e8\u30c7\u30fc\u30bf\u3078\u306e\u6c4e\u5316\u6027\u80fd\u304c\u60aa\u304f\u306a\u308b\u3053\u3068(\u30aa\u30fc\u30d0\u30fc\u30d5\u30a3\u30c3\u30c6\u30a3\u30f3\u30b0\u73fe\u8c61)\u304c\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

[7] \u6cbb\u7642\u958b\u59cb\u5f8c6-8\u9031
\u3000\u4e00\u822c\u7684\u306b\u3001\u6297\u3046\u3064\u85ac\u306b\u3088\u308b\u3046\u3064\u75c7\u72b6\u306e\u6539\u5584\u5ea6\u306e\u8a55\u4fa1\u306f\u3001\u6295\u85ac\u6cbb\u7642\u3092\uff16\u9031\u9593\u4ee5\u4e0a\u884c\u3063\u305f\u5f8c\u306b\u5b9f\u65bd\u3057\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u6297\u3046\u3064\u85ac\u6cbb\u7642\u306b\u3088\u308b\u8133\u6d3b\u52d5\u306e\u5909\u5316\u306b\u3064\u3044\u3066\u3001\u6cbb\u7642\u958b\u59cb\u5f8c6-8\u9031\u306e\u9593\u306b\u64ae\u50cf\u3057\u305ffMRI\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3066\u691c\u8a0e\u3092\u884c\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

[8] \u9078\u629e\u7684\u30bb\u30ed\u30c8\u30cb\u30f3\u518d\u53d6\u308a\u8fbc\u307f\u963b\u5bb3\u85ac(SSRI)
\u3000\u3046\u3064\u75c5\u6cbb\u7642\u306b\u304a\u3044\u3066\u3001\u6a19\u6e96\u7684\u306b\u4f7f\u7528\u3055\u308c\u308b\u6297\u3046\u3064\u85ac\u306e\u4e00\u3064\u3067\u3059\u3002\u9078\u629e\u7684\u30bb\u30ed\u30c8\u30cb\u30f3\u518d\u53d6\u308a\u8fbc\u307f\u963b\u5bb3\u85ac(SSRI)\u306f\u3001\u30b7\u30ca\u30d7\u30b9\u306b\u304a\u3051\u308b\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u518d\u53d6\u308a\u8fbc\u307f\u963b\u5bb3\u4f5c\u7528\u3092\u5171\u901a\u306e\u85ac\u7406\u5b66\u7684\u7279\u5fb4\u3068\u3057\u3066\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u4e00\u822c\u7684\u306b\u6297\u3046\u3064\u52b9\u679c\u767a\u73fe\u307e\u3067\u306b\u306f4-6\u9031\u9593\u306f\u304b\u304b\u308b\u3053\u3068\u304c\u591a\u304f\u3001\u89e3\u6c7a\u3059\u3079\u304d\u5927\u304d\u306a\u554f\u984c\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

[9]\u8133\u306e\u90e8\u4f4d\u306b\u3064\u3044\u3066
\u30fb\u5de6\u80cc\u5916\u5074\u524d\u982d\u524d\u91ce (Left dorsolateral prefrontal cortex: L-DLPFC)
\u3000\u610f\u601d\u6c7a\u5b9a\u3084\u30ef\u30fc\u30ad\u30f3\u30b0\u30e1\u30e2\u30ea(\u4f5c\u696d\u8a18\u61b6\u3068\u547c\u3070\u308c\u308b\u77ed\u671f\u8a18\u61b6)\u3001\u793e\u4f1a\u7684\u8a8d\u77e5\u3084\u3001\u8a8d\u77e5\u7684\u67d4\u8edf\u6027\u306a\u3069\u306e\u6a5f\u80fd\u3068\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002\u8ab2\u984c\u6642\u306e\u8133\u6a5f\u80fd\u6d3b\u52d5\u3068\u3057\u3066\u73fe\u308c\u308b\u5b9f\u884c\u5236\u5fa1\u30cd\u30c3\u30c8\u30ef\u30fc\u30af(Executive Control Network; ECN)\u306b\u304a\u3044\u3066\u4e2d\u5fc3\u7684\u306a\u8133\u9818\u57df\u3067\u3059\u3002
\u30fb\u5f8c\u90e8\u5e2f\u72b6\u56de\/\u6954\u524d\u90e8 (Posterior cingulate cortex: PCC \/ Precuneus)
\u3000\u611f\u60c5\u3084\u8a18\u61b6\u3001\u5185\u767a\u7684\u306a\u5236\u5fa1\u3001\u6ce8\u610f\u306e\u96c6\u4e2d\u306a\u3069\u306e\u6a5f\u80fd\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002\u5b89\u9759\u6642\u306e\u8133\u6a5f\u80fd\u6d3b\u52d5\u3068\u3057\u3066\u73fe\u308c\u308b\u30c7\u30d5\u30a9\u30eb\u30c8\u30e2\u30fc\u30c9\u30cd\u30c3\u30c8\u30ef\u30fc\u30af(Default Mode Network; DMN)\u306b\u304a\u3051\u308b\u4e2d\u5fc3\u7684\u306a\u8133\u9818\u57df\u3067\u3059\u3002<\/p>\n\n\n\n

\u3010\u8ad6\u6587\u3011
\u63b2\u8f09\u8a8c: Scientific Reports
\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb: Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants(\u30e1\u30e9\u30f3\u30b3\u30ea\u30fc\u578b\u3046\u3064\u75c5\u306b\u95a2\u308f\u308b\u8133\u6a5f\u80fd\u7d50\u5408\u3068\u6297\u3046\u3064\u85ac\u306b\u3088\u308b\u5909\u5316)
\u8457\u8005\u540d: Ichikawa N1, Lisi G2, Yahata N3, Okada G1, Takamura M1, Hashimoto R4, Yamada T2, Yamada M3, Suhara T3, Moriguchi S5, Mimura M5, Yoshihara Y6, Takahashi H7, Kasai K8, Kato N4, Yamawaki S1, Seymour B2,9, Kawato M2, Morimoto J2, Okamoto Y1*
\u6240\u5c5e\uff1a1\u5e83\u5cf6\u5927\u5b66\u5927\u5b66\u9662\u30012\u56fd\u969b\u96fb\u6c17\u901a\u4fe1\u57fa\u790e\u6280\u8853\u7814\u7a76\u6240(ATR)\u30013\u91cf\u5b50\u79d1\u5b66\u6280\u8853\u7814\u7a76\u958b\u767a\u6a5f\u69cb\u30014\u662d\u548c\u5927\u5b66\u30015\u6176\u61c9\u7fa9\u587e\u5927\u5b66\u30016\u4eac\u90fd\u5927\u5b66\u30017\u6771\u4eac\u533b\u79d1\u6b6f\u79d1\u5927\u5b66\u30018\u6771\u4eac\u5927\u5b66\u30019\u30b1\u30f3\u30d6\u30ea\u30c3\u30b8\u5927\u5b66<\/p>\n\n\n\n

\u3010\u7814\u7a76\u30b5\u30dd\u30fc\u30c8\u3011
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